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DEPARTAMENT de BIOQUIMICA i BIOLOGIA MOLECULAR



























Recerca > Grups d'Investigació

Grup d'estudi de les Neurotoxines Clostridials




Dades bàsiques




Àrees Investigació
BIOQUÍMICA I BIOLOGIA MOLECULAR DEL SISTEMA NERVIÓS

Investigador/s
José Aguilera Avila
Tel: 8520
enviar e-mail

Personal
Mireia Herrando (Tècnica de suport a la recerca); Roger Cubí (Professor associat); Natalia Moreno (Professora associada)






Descriptor




La toxina tetànica és una neurotoxina de la mateixa família que les neurotoxines botulíniques, responsables del botulisme. Aquestes últimes han estat emprades de forma terapèutica amb èxit en el tractament de patologies degudes a contractures musculars alterades, com l’estrabisme, la paràlisi cerebral, la contractura anal, o el torticolis. Darrerament aquestes toxines s’han aplicat fins i tot en l’àmbit cosmètic contra les arrugues. Per a aquests usos terapèutics i cosmètics, els científics treballen amb dosis subletals de les toxines.


Publicacions




Carles Gil, Roger Cubí­, José Aguilera (2007)
Shedding of the p75NTR neurotrophin receptor is modulated by lipid rafts.
FEBS Lett. Vol: 581, 1851-8

Carles Gil, Roger Cubí­, Juan Blasi, José Aguilera (2006)
Synaptic proteins associate with a sub-set of lipid rafts when isolated from nerve endings at physiological temperature.
Biochem. Biophys. Res. Commun. Vol: 348 1334-42

Carles Gil, Alex Soler-Jover, Juan Blasi, José Aguilera (2005)
Synaptic proteins and SNARE complexes are localized in lipid rafts from rat brain synaptosomes.
Biochem. Biophys. Res. Commun. Vol: 329 117-24

Imane Chaïb-Oukadour, Carles Gil, José Aguilera (2004)
The C-terminal domain of the heavy chain of tetanus toxin rescues cerebellar granule neurones from apoptotic death: involvement of phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways.
J. Neurochem. Vol: 90 1227-36

Carles Gil, Abderrahim Najib, José Aguilera (2003)
Serotonin transport is modulated differently by tetanus toxin and growth factors.
Neurochem. Int. Vol: 42 535-42

Carles Gil, Imane Chaib-Oukadour, José. Aguilera (2003)
C-terminal fragment of tetanus toxin heavy chain activates Akt and MEK/ERK signalling pathways in a Trk receptor-dependent manner in cultured cortical neurons.
Biochem. J. Vol: 373 613-20

P. Pelliccioni, C. Gil, A. Najib, E. Sarri, F. Picatoste, J. Aguilera (2001)
Tetanus toxin modulates serotonin transport in rat-brain neuronal cultures.
J. Mol. Neurosci. Vol: 17 303-10

C. Gil, I. Chaib-Oukadour, J. Blasi, J. Aguilera (2001)
HC fragment (C-terminal portion of the heavy chain) of tetanus toxin activates protein kinase C isoforms and phosphoproteins involved in signal transduction.
Biochem. J. Vol: 356 97-103

C. Gil, I. Chaïb-Oukadour, P. Pelliccioni, J. Aguilera (2000)
Activation of signal transduction pathways involving trkA, PLC?-1, PKC isoforms and ERK-1/2 by tetanus toxin.
FEBS Lett. Vol: 481 177-82

A. Najib, P. Pelliccioni, C. Gil, J. Aguilera (2000)
Serotonin transporter phosphorylation modulated by tetanus toxin.
FEBS Lett. Vol: 486 136-42

A. Najib, P. Pelliccioni, C. Gil, J. Aguilera (1999)
Clostridium neurotoxins influence serotonin uptake and release differently in rat brain synaptosomes.
J. Neurochem. Vol: 72 1991-8

M. Riera, N. Roher, F. Miró, C. Gil, R. Trujillo, J. Aguilera, M. Plana, E. Itarte (1999)
Association of protein kinase CK2 with eukaryotic translation initiation factor eIF-2 and with grp94/endoplasmin.
Mol. Cell. Biochem. Vol: 191 97-104

C. Gil, P. Pelliccioni, E. Itarte, J. Aguilera (1999)
Differential action of nerve growth factor and phorbol ester TPA on rat synaptosomal PKC isoenzymes.
Neurochem. Int. Vol: 35 281-91

J. Inserte, A. Najib, P. Pelliccioni, C. Gil, J. Aguilera (1999)
Inhibition by tetanus toxin of sodium-dependent, high-affinity [3H]5-hydroxytryptamine uptake in rat synaptosomes.
Biochem. Pharmacol. Vol: 57 111-20

C. Gil, M. Ruiz-Meana, M. Alava, E. Yavin, J. Aguilera (1998)
Tetanus toxin enhances protein kinase C activity translocation and increases polyphosphoinositide hydrolysis in rat cerebral cortex preparations.
J. Neurochem. Vol: 70 1636-43

C. Gil, M. Plana, M. Riera, E. Itarte (1996)
Rat liver pp49, a protein that forms complexes with protein kinase CK2, is composed of the beta and the gamma subunits of translation initiation factor eIF-2.
Biochem. Biophys. Res. Commun. Vol: 225 1052-7